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KMID : 0043320170400040518
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Archives of Pharmacal Research
2017 Volume.40 No. 4 p.518 ~ p.523
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Spatholobus suberectus Dunn. constituents inhibit sortase A and Staphylococcus aureus cell clumping to fibrinogen
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Cho Hyun-Joo
Chung Beom-Koo
Kim Chang-Kwon
Oh Dong-Chan
Oh Ki-Bong
Shin Jong-Heon
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Abstract
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Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus (S. aureus), deletion of sortase isoform results in a significant reduction in virulence and infection potential. Twenty flavonoids were isolated from the stem of the folk medicinal plant Spatholobus suberectus Dunn. These compounds were tested against S. aureus-derived sortase A (SrtA), a key transpeptidase for bacterial virulence. Among these active flavonoids, 7-hydroxy-6-methoxy-flavanone (3) and formononetin (10) were identified as compounds with promising SrtA inhibitory activity. These compounds also exhibited inhibitory activity against S. aureus cell clumping to fibrinogen. The suppression of cell-clumping activity indicates the potential of these compounds in the treatment of S. aureus infections via the inhibition of SrtA.
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KEYWORD
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Spatholobus suberectus Dunn., Flavonoids, Staphylococcus aureus, Sortase A inhibition, Cell clumping
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